The PlA1/PlA2 polymorphism lies throughout the gene with the ?three (GPIIIa) subunit of ?IIb?3 (GPIIb-IIIa). This integrin serves being a receptor for adhesive proteins fibrinogen and von Willebrand factor and it is important to the cohesive properties of platelets. Recognition of those proteins as soluble ligands needs ?IIb?3 to generally be activ